Which hepatocyte will it be? Hepatocyte choice for bioartificial liver support systems

Bioartificial liver support: developments in hepatocyte culture and bioreactor design.

Bioartificial liver devices aim to support patients with acute liver failure (ALF) until orthotopic liver transplantation (OLT) or spontaneous recovery due to hepatic regeneration can occur. However, initial clinical experiences with two devices have indicated that functional efficacy in this setting may be less than in the experimental situation. Several fundamental issues remain unresolved, i...

Novel quantitative tools for engineering analysis of hepatocyte cultures in bioartificial liver systems.

Extracorporeal bioartificial liver devices (BAL) are perhaps among the most promising technologies for the treatment of liver failure, but significant technical challenges remain in order to develop systems with sufficient processing capacity and of manageable size. One key limitation is that during BAL operation, when the device is exposed to plasma from the patient, hepatocytes are prone to a...

Liver, Hepatocyte – Glycogen accumulation Liver, Hepatocyte – Glycogen depletion

Figure Legend: Figure 1 Glycogen accumulation–normal accumulation in hepatocytes in a female B6C3F1 mouse from a chronic study. Figure 2 Glycogen accumulation–normal mobilization of glycogen from centrilobular area in a male B6C3F1 mouse from a subchronic study. Figure 3 Glycogen accumulation–glycogen in all hepatocytes in a male B6C3F1 mouse from a subchronic study. Figure 4 Glycogen depletion...

Liver, Hepatocyte – Karyomegaly

Comment: Though karyomegaly is predominantly a nuclear change, Figures 1 and 2 (arrow) show enlargement of both hepatocyte cytoplasm and nuclei. The change is throughout the hepatic lobule but is more prominent in the centrilobular areas. The increase in nuclear size is consistent with polyploidy, but in this subchronic study, the severity is significantly greater than one would expect at this ...

Liver, Hepatocyte – Hypertrophy